Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.

Key words

Regenerative Medicine

Mesenchymal Stem Cell Transplantation

Platelet-Poor Plasma

Apical periodontitis

Mature teeth

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Postgraduate Certificate

Year 1 of the MSc in Endodontology. An additional 6 days of study, perfecting everything you have learned from the 10 day programme to OSCE standards.

Postgraduate Diploma

Year 2 of the MSc in Endodontology. 12 days of studying advanced topics such endodontic microscopy, innovations in endodontics, research methods and statistics.

MSc in Endodontology

Year 3 of the MSc in Endodontology and the final component for the Masters Degree. You’re given approximately 12 months to submit a dissertation based on an endodontic topic of your choosing. You’ll be appointed a personal supervisor to who will provide 1:1 coaching.